“Heaven Knows What” is a difficult film to sit through. Directors Ben and Joshua Safdie aren’t interested in crafting an overview of heroin addiction and homelessness, they want viewers to live alongside the characters, feeling every drowsy step and rambling thought. It’s certainly a challenge to process the story and learn to accept discomfort, but the reward is an evocative look at lost souls in New York City, updating “Panic in Needle Park” for a new generation of ailing young people who don’t have a future. Again, there are mental and physical endurance issues to consider before buying a ticket, but underneath the thick layer of disease remains a potent look at the demands of self-medication. Read the rest at Blu-ray.com

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